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A Closer Look at the Endocannabinoid System

A Closer Look at the Endocannabinoid System

Have you ever been high and asked yourself what is the science is behind being high? Me neither. I am certainly happy that I did, though. The Endocannabinoid System or ECS is a system of lipid retrograde neurotransmitters that bind to cannabinoid receptors—the cannabinoid receptor proteins are kicked into action, bobbing and weaving throughout the vertebrate central nervous system and peripheral nervous system. Retrograde means that they’re returning to where they belong. There are two sub receptors known as CB1 and CB2 (cannabinoid receptor). Both of these are G protein-coupled receptors from the cannabinoid receptor family.

All mammals have an endocannabinoid system, splitting convoluted vessels of receptors throughout your body, and they love interacting with cannabis. So, stop dabbing in the vicinity of your pet. The ECS has an essential role in neural functions such as mood, memory, learning, pain, and addictive-based behavior. CB1 is present in the peripheral nervous system, the central nervous system, retina, the pituitary gland, and the thyroid gland. It plays a heavy hand in moderating the cannabinoid effects binding together and giving us the munchies.CB1 oversees a majority of the system.

CB2 is present in the immune system, gastrointestinal system, metabolism, bones, and muscles. It is mainly responsible for handling the psychoactive properties of tetrahydrocannabinol THC. CB2 has allowed scientists to discover therapeutic treatments for those with GI issues, such as Crohn’s and IBS. CB2 accompanies CB1 in the brain, the central nervous system specifically but plays a minor role. Interestingly enough, CB1 and CB2 can provide support for one symptom in different areas.

The activation of these receptors is known as biphasic; it means that a substance can produce different behaviors at different doses. This applies to both THC and CBD. Too much THC can spike anxiety and paranoia. Too much CBD will put you to sleep. Too little CBD could give you too much of a pick-me-up, onsetting anxiety.  Full-Spectrum CBD provides additional cannabinoids such as THCa,THCv,CBG, CBDa, CBDv, CBC and CBN. When these compounds mesh, it is called the entourage effect. This leads to better results, amplifying the medicinal benefits. The trick is finding what works for you; it involves experimenting until you find your sweet spot. It is a little easier to find your sweet spot with THC. Higher activity in the ECS with THC does indeed affect short-term memory. But it is only a temporary condition, and it is reversible.

This system is our gift; it allows us to consume THC and CBD products, putting on a show of medicinal value. It is how we react to cannabis, the emotions, the behavioral changes, and the heavy head euphoria. Because the ECS being in preliminary research, there is still a fair amount of mystery behind this seemingly important system. We have all read or heard a personal experience with cannabis that is heartwarming, whether it allowed that person to feel pain-free, to be able to eat, or gave someone that extra push to get a whole night’s rest. The ECS highlights the research gaps, pinpointing where exactly the issues are. This determines how they can treat specific ailments based on location in the body. The physiological aspects lead to remarkable stories, journeys to recovery, and providing peace for others. Proper education in cannabis can change minds.