March 5, 2022

Jen Hight

Cannabis

A Closer Look at the Endocannabinoid System

The Endocannabinoid System or ECS is a system of lipid retrograde neurotransmitters that bind to cannabinoid receptors—the cannabinoid receptor proteins are kicked into action, bobbing and weaving throughout the vertebrate central nervous system and peripheral nervous system. Retrograde means that they’re returning to where they belong. There are two sub receptors known as CB1 and CB2 (cannabinoid receptor). Both of these are G protein-coupled receptors from the cannabinoid receptor family.

All mammals have an endocannabinoid system, splitting convoluted vessels of receptors throughout your body, and they love interacting with cannabis. So, stop dabbing in the vicinity of your pet. The ECS is referenced in some studies about neural functions such as mood, memory, learning, pain, and addictive-based behavior. CB1 is present in the peripheral nervous system, the central nervous system, retina, the pituitary gland, and the thyroid gland.

CB2 is present in the immune system, gastrointestinal system, metabolism, bones, and muscles. It is mainly responsible for handling the psychoactive properties of tetrahydrocannabinol THC. CB2 has allowed scientists to do research on GI issues, such as Crohn’s and IBS. CB2 accompanies CB1 in the brain, the central nervous system specifically but plays a minor role. Interestingly enough, CB1 and CB2 can provide support for one symptom in different areas.

The activation of these receptors is known as biphasic. This applies to both THC and CBD. Full-Spectrum CBD provides additional cannabinoids such as THCa, THCv,  CBG, CBDa, CBDv, CBC and CBN. When these compounds mesh, it is called the entourage effect. This leads to better results. The trick is finding what works for you; it involves experimenting until you find your sweet spot.

This system is our gift. Because the ECS being in preliminary research, there is still a fair amount of mystery behind this seemingly important system. We have all read or heard a personal experience with cannabis that is heartwarming. The ECS highlights the research gaps, potentially pinpointing where exactly the issues are. Proper education in cannabis can change minds.